UPO book

Brief Research Description

• Pathogenic mechanisms of Acute Kidney Injury (AKI): role of plasma extracellular vesicles (EVs) and Gram negative-derived LPS and Quorum Sensing.

• AKI to Chronic Kidney Disease (CKD) transition: biomarker discover studies and identification of pathways involved in the progression from AKI to CKD. Development of drugs able to interfere with kidney aging.

• Extracorporeal Blood Purification Therapies in sepsis-induced AKI: protective role of different types of membranes and devices able to enhance the clearance of detrimental humoral mediators.

• Inflammation in chronic hemodialysis patients: role of uremic toxins in early vascular aging, cardiovascular events and cognitive decline.

• New therapeutic approaches to limit ischemia-reperfusion injury (IRI), viral infections and rejection in kidney transplantation.

• Protective role of stem cell-derived extracellular vesicles in experimental models of AKI, glomerular diseases and kidney transplantation.

Keywords

Acute Kidney Injury, kidney transplantation, extracorporeal blood purification therapies, extracellular vesicles, kidney aging.

PubMed