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Brief Research Description

Her laboratory is mainly focused on research projects on the genetics of Autoimmune and neurodegenerative diseases The research activities are co-coordinated with  Prof. Lucia Corrado and Prof. Nadia Barizzone

The current research interests of her group include: i) the genetics of multiple sclerosis (MS) with a focus on the identification and functional characterization with high-throughput and multiomic approaches of loci involved in MS susceptibility  and in the clinical phenotype and disease severity and progression on large and clinically well-characterized cohorts and taking advantage of the group’s coordination of national multicentric networks and  the participation to international consortia  ii) the development of prognostic models and scores to predict MS disease activity and progression, integrating genetic, clinical, and environment exposure data using machine learning tools. iii) the genetics of Amyotrophic Lateral Sclerosis (ALS) and other neurodegenerative diseases (Frontotemporal dementia, Parkinson, Spinocerebellar Ataxia) with a focus on the identification of novel ALS causative genes from whole genome sequencing data coupling bioinformatic prioritization tools with in vitro high-throughput functional assays, thanks to the coordination and collaboration with national and international multicentric project.

Keywords

Neurogenetics, multiple sclerosis, amyotrophic lateral sclerosis, neurodegenerative diseases, multiomics

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