Embedded Files
Research Activity
Research Activity
Brief Research Description
Works on signal transduction with a specific interest in the biological role of lipid kinases in immune cell function and cell transformation.
Involvement of DGKα in XLP-1 and WAS primary immunodeficiencies, focusing on its role in T lymphocyte signalling and regulation by the SAP–WASp signaling pathway.
Development of a new class of DGKs inhibitors in view of therapeutic use.
Phosphatidic acid regulated proteins and pathways downstream to DGKs and PLDs. Involvement of phosphatidic acid regulated proteins in signaling of lymphocytes and transformed cells.
Control of DGKs activity and their role in cell transformation. Study of tyrosine kinase and second messenger signaling regulating lipid kinase activity in transformed cells with a specific focus on DGKα role in cell survival, immune evasion and angiogenesis.
Past research activities: i) Signalling pathways promoting hepatocyte survival in preconditioned liver; ii) anti-apoptotic and pro-differentiative proprieties of Ghrelin; iii) lipidomic and peptidomic studies on COVID-19 patients.
Keywords
Primary immunodeficiency, cell transformation, immune signaling, lipid kinase, T lymphocyte
Page updated
Report abuse